First-Pass-Effect

First-Pass-Effect
First-Pass-Ef|fect
['fə:st'pɑ:s|i'fɛkt] der; -, -s
<zu engl. first »Erster«, pass »Zugang, Durchgang« u. effect »Wirkung«>
teilweise od. vollständige Verminderung der Bioverfügbarkeit eines durch den Mund verabreichten Arzneimittels durch Veränderungen im Stoffwechselprozess (Med.)

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